Screening Strategies for a Sustainable Endpoint for Gambiense Sleeping Sickness
نویسندگان
چکیده
منابع مشابه
Evaluation of LATEX/T.b.gambiense for mass screening of Trypanosoma brucei gambiense sleeping sickness in Central Africa.
We compared the Card Agglutination Test for Trypanosomiasis (CATT), which consists of lyophilized bloodstream form trypomastigotes of Trypanosoma brucei gambiense (T.b.g.) variable antigen type LiTat 1.3, with LATEX/T.b.g., which consists of a lyophilized suspension of latex particles coated with variable surface glycoproteins of T.b.g. variable antigen types LiTat 1.3, 1.5 and 1.6. This study ...
متن کاملDo Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?
Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination ...
متن کاملGambiense sleeping sickness: re-emerging and soon untreatable?
Towards the end of the 1950s, sleeping sickness caused by Trypanosoma brucei gambiense was believed to be on the verge of eradication. Today, however, it has returned with a vengeance, mainly because of a deterioration of control activities, severe disruptions of health services, and population movements into high-risk areas. For example, over the last ten years, annual detection rates of the d...
متن کاملHow to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness.
BACKGROUND. Clinical management of human African trypanosomiasis requires patient follow-up of 2 years' duration. At each follow-up visit, cerebrospinal fluid (CSF) is examined for trypanosomes and white blood cells (WBCs). Shortening follow-up would improve patient comfort and facilitate control of human African trypanosomiasis. METHODS. A prospective study of 360 patients was performed in the...
متن کاملPerformance of Parasitological and Molecular Techniques for the Diagnosis and Surveillance of Gambiense Sleeping Sickness
OBJECTIVES Recently, improvements have been made to diagnostics for gambiense sleeping sickness control but their performance remains poorly documented and may depend on specimen processing prior to examination. In a prospective study in the Democratic Republic of the Congo, we compared the diagnostic performance of several parasite detection techniques, immune trypanolysis and of m18S PCR on w...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2019
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiz588